Ssa Antibody Reference Range

Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.

Ssa antibody reference range.

Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. 60 70 of cases systemic lupus erythematosus sle. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases.

Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. The reference range of anti ro antibodies is negative.

Anti ro levels may be elevated in the following conditions. 25 of cases both anti ro ssa and. Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.

A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light. Lupus erythematosus le 40 60 of. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

The reference range of anti ro antibodies is negative. Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. Ss b la is composed of a 48 kd protein combined with rna species. Ss a ro antibodies occur in patients with several different connective tissue.