Ssa Antibody Range

Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

Ssa antibody range.

Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Anti ro ssa is produced in the cytoplasm of cells in the epidermal layer of the skin following uv irradiation. Ss a ro antibodies occur in patients with several different connective tissue. Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses.

When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus. The reference range of anti ro antibodies is negative. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.

Anti ro52 antibodies in particular have been tied to elevated photosensitivity. Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.

Both anti ssa and anti ssa are usually absent in secondary sjögren s syndrome. Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. This has been termed antiphospholipid antibody syndrome. Lower likelihood of anti dna antibodies.

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. It is not a specific enough test to determine a definitive diagnosis in a majority of patients but it can be used with other tools and tests to determine if lupus is present. Anti ssa plus anti la ssb is associated with the following factors.

Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Ro antigens are simultaneously upregulated on the cell surface resulting in the anti ro ssa antibody marking cells for destruction. Ss b la is composed of a 48 kd protein combined with rna species. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.

Lupus erythematosus le 40 60 of.